The 2010 National Rugby League season is the 103rd season of professional rugby league football club competition in Australia, and the thirteenth run by the NRL. The season will commence on March 12th with concurrent matches in Sydney and Brisbane in which the Parramatta Eels played St. George-Illawarra Dragons at Parramatta Stadium while the Brisbane Broncos played North Queensland Cowboys at Suncorp Stadium. The season will end with the Grand Final, played on October 3 at ANZ Stadium.

For the fourth consecutive year, sixteen teams compete for the Telstra Premiership.